![]() The Krebs cycle, or theĬitric acid cycle. Overview video- we know what the next step is. Kind of like organsĭo specific things within our own bodies. The organelles, you kind of view them as parts of the cell This space out here that's between the organelles- and Structure of a mitochondria, maybe later in this video It has an outer membraneĪnd an inner membrane just like that. And there's a reason why peopleĬall it the power centers of the cell. It has its DNA and its chromatinįorm all spread around like that. Maybe its nucleus, we'reĭealing with a eukaryotic cell. This a little bit better, let me draw a cell right here. So on a net basis, it generatedįour, used two, it gave us two ATPs. And I always say the net there,īecause remember, it used two ATPs in that investment And this is what happenedĪbsence of oxygen. ![]() Internet or on Wikipedia and see them in detail. You could look up their chemical structures on the Lot of other stuff going on in the carbons. Molecule, that this essentially gets split in halfīy glycolysis and we end up 2 pyruvic acids or two Start off with a glucose molecule, which is a 6-carbon The first picture on this website shows a picture of MPC 1/2 (different types of the MPC protein) on the inner membrane, transporting pyruvate into the matrix. I focused on reading the abstract/introduction, as the experimental processes used to identify and describe the MPC were a bit technical for my Sunday brain :) This is the journal where I got this information from if you'd like to have a look yourself. It uses ATP, which it is able to recuperate by the vast amounts of ATP that are created by each molecule of pyruvate through oxidative phosphorylation. They are embedded in the inner membrane and use ATP to transport pyruvate into the matrix. Pyruvate transport into the matrix is accomplished therefore by active transport by a class of recently discovered transport proteins called mitochondrial pyruvate carriers (MPC). This is an important site in the large-scale energy production process and we don't want all kinds of molecules contaminating this space. Getting across the inner membrane and into the matrix, however, is a different story.Įntry into the matrix is much more restrictive, and rightfully so. Pyruvate carries a negative charge, and there are anion channels that allow pyruvate to penetrate the intermembrane space by simple passive diffusion! No energy is required. Getting across the outer mitochondrial membrane is relatively easy. I had to do a bit of research, because I've taught cellular respiration many times, but never looked in detail at exactly how pyruvate gets into the matrix.
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